Comprehensive Characterization of a Next-Generation Antiviral T-Cell Product and Feasibility for Application in Immunosuppressed Transplant Patients

Comprehensive Characterization of a Next-Generation Antiviral T-Cell Product and Feasibility for Application in Immunosuppressed Transplant Patients

Viral infections have a major impact on morbidity and mortality of immunosuppressed solid organ transplant (SOT) patients because of missing or failure of adequate pharmacologic antiviral treatment. Adoptive antiviral T-cell therapy (AVTT), regenerating disturbed endogenous T-cell immunity, emerged...

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Bibliographic Details
Main Authors: Leila Amini, Tino Vollmer, Desiree J. Wendering, Anke Jurisch, Sybille Landwehr-Kenzel, Natalie Maureen Otto, Karsten Jürchott, Hans-Dieter Volk, Petra Reinke, Michael Schmueck-Henneresse
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
cytomegalovirus
adoptive T-cell therapy
solid organ transplantation
Rapamycin
mTOR
immune regeneration
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01148/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01148/full

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