R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids.

R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids.

BACKGROUND: R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still unclear. METHODOLOGY/PRINCIPAL FINDINGS: We show that R-flurbiprofen reduces gluta...

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Bibliographic Details
Main Authors: Philipp Bishay, Helmut Schmidt, Claudiu Marian, Annett Häussler, Nina Wijnvoord, Simone Ziebell, Julia Metzner, Marco Koch, Thekla Myrczek, Ingo Bechmann, Rohini Kuner, Michael Costigan, Faramarz Dehghani, Gerd Geisslinger, Irmgard Tegeder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2869361?pdf=render

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http://europepmc.org/articles/PMC2869361?pdf=render

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