Nrf2 participates in mechanisms for reducing the toxicity and enhancing the antitumour effect of Radix Tripterygium wilfordii to S180-bearing mice by herbal-processing technology

Context: Radix Tripterygium wilfordii Hook. f. (Celastraceae) (LGT) has outstanding curative efficacy; however, side effects include high toxicity, particularly hepatotoxicity and nephrotoxicity. Objective: To investigate detoxification mechanisms of LGT through processing separately with each of th...

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Bibliographic Details
Main Authors: Jun-Ming Wang, Jin-Yang Li, Hong Cai, Rong-Xing Chen, Yue-Yue Zhang, Lu-Lu Zhang, Ying Cui, Yong-Xian Cheng
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Pharmaceutical Biology
Subjects:
Online Access:http://dx.doi.org/10.1080/13880209.2019.1634106