ID1 mediates resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer through epithelial–mesenchymal transition

ID1 mediates resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer through epithelial–mesenchymal transition

Abstract Background ID1 is associated with resistance to the first generation of EGFR tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer (NSCLC). However, the effect of ID1 expression on osimertinib resistance in EGFR T790M-positive NSCLC is not clear. Methods We established a drug...

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Bibliographic Details
Main Authors: Kejun Liu, Xianwen Chen, Ligang Wu, Shiyuan Chen, Nianxin Fang, Limin Cai, Jun Jia
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Pulmonary Medicine
Subjects:
ID1
Osimertinib
Drug resistance
EGFR T790M
Non-small-cell lung cancer (NSCLC)
Epithelial–mesenchymal transition (EMT)
Online Access:https://doi.org/10.1186/s12890-021-01540-4

Internet

https://doi.org/10.1186/s12890-021-01540-4

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