Synthesis and Physicochemical Characterization of the Process-Related Impurities of Olmesartan Medoxomil. Do 5-(Biphenyl-2-yl)-1-triphenylmethyltetrazole Intermediates in Sartan Syntheses Exist?

Synthesis and Physicochemical Characterization of the Process-Related Impurities of Olmesartan Medoxomil. Do 5-(Biphenyl-2-yl)-1-triphenylmethyltetrazole Intermediates in Sartan Syntheses Exist?

During the process development for multigram-scale synthesis of olmesartan medoxomil (OM), two principal regioisomeric process-related impurities were observed along with the final active pharmaceutical ingredient (API). The impurities were identified as N-1- and N-2-(5-methyl-2-oxo-1,3-dioxolen-4-y...

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Bibliographic Details
Main Authors: Iwona Dams, Anna Ostaszewska, Maria Puchalska, Justyna Chmiel, Piotr Cmoch, Iwona Bujak, Agata Białońska, Wojciech J. Szczepek
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
crystal structure
impurities
medoxomil
NMR spectroscopy
olmesartan
prodrugs
regioisomers
sartans
structure
synthesis
Online Access:http://www.mdpi.com/1420-3049/20/12/19762

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http://www.mdpi.com/1420-3049/20/12/19762

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