Synthesis and Physicochemical Characterization of the Process-Related Impurities of Olmesartan Medoxomil. Do 5-(Biphenyl-2-yl)-1-triphenylmethyltetrazole Intermediates in Sartan Syntheses Exist?
During the process development for multigram-scale synthesis of olmesartan medoxomil (OM), two principal regioisomeric process-related impurities were observed along with the final active pharmaceutical ingredient (API). The impurities were identified as N-1- and N-2-(5-methyl-2-oxo-1,3-dioxolen-4-y...
Main Authors: | Iwona Dams, Anna Ostaszewska, Maria Puchalska, Justyna Chmiel, Piotr Cmoch, Iwona Bujak, Agata Białońska, Wojciech J. Szczepek |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-12-01
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Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/20/12/19762 |
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