MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning

MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning

Methyl-CpG-binding protein 2 (MeCP2) encoded by the MECP2 gene is a transcriptional regulator whose mutations cause Rett syndrome (RTT). Mecp2-deficient mice show fear regulation impairment; however, the cellular and molecular mechanisms underlying this abnormal behavior are largely uncharacterized....

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Bibliographic Details
Main Authors: Ying Zhang, Yi Zhu, Shu-Xia Cao, Peng Sun, Jian-Ming Yang, Yan-Fang Xia, Shi-Ze Xie, Xiao-Dan Yu, Jia-Yu Fu, Chen-Jie Shen, Hai-Yang He, Hao-Qi Pan, Xiao-Juan Chen, Hao Wang, Xiao-Ming Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
MeCP2
nucleus accumbens
cholinergic interneurons
fear learning
GABAA α2 receptor
Online Access:https://elifesciences.org/articles/55342

Internet

https://elifesciences.org/articles/55342

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