Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms

Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms

A fundamental part of the immune response to infection or injury is leukocyte migration. Matrix metalloproteinases (MMPs) are a class of secreted or cell-bound endopeptidases, implicated in every step of the process of inflammatory cell migration. Hence, specific inhibition of MMPs is an interesting...

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Bibliographic Details
Main Authors: Elisa Nuti, Armando Rossello, Doretta Cuffaro, Caterina Camodeca, Jens Van Bael, Dries van der Maat, Erik Martens, Pierre Fiten, Rafaela Vaz Sousa Pereira, Estefania Ugarte-Berzal, Mieke Gouwy, Ghislain Opdenakker, Jennifer Vandooren
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
MMP-9
inflammation
endotoxemia
leukocytosis
chemotaxis
sepsis
Online Access:https://www.mdpi.com/2073-4409/9/7/1634

Internet

https://www.mdpi.com/2073-4409/9/7/1634

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