Dissociation rate compensation mechanism for budding yeast pioneer transcription factors

Dissociation rate compensation mechanism for budding yeast pioneer transcription factors

Nucleosomes restrict the occupancy of most transcription factors (TF) by reducing binding and accelerating dissociation, while a small group of TFs have high affinities to nucleosome-embedded sites and facilitate nucleosome displacement. To understand this process mechanistically, we investigated tw...

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Bibliographic Details
Main Authors: Benjamin T Donovan, Hengye Chen, Caroline Jipa, Lu Bai, Michael G Poirier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
Reb1
nucleosomes
pioneer factors
binding and dissociation kinetics
single molecule
Online Access:https://elifesciences.org/articles/43008

Internet

https://elifesciences.org/articles/43008

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