A Novel t(8;14)(q24;q11) Rearranged Human Cell Line as a Model for Mechanistic and Drug Discovery Studies of NOTCH1-Independent Human T-Cell Leukemia

A Novel t(8;14)(q24;q11) Rearranged Human Cell Line as a Model for Mechanistic and Drug Discovery Studies of NOTCH1-Independent Human T-Cell Leukemia

MYC-translocated T-lineage acute lymphoblastic leukemia (T-ALL) is a rare subgroup of T-ALL associated with CDKN2A/B deletions, PTEN inactivation, and absence of NOTCH1 or FBXW7 mutations. This subtype of T-ALL has been associated with induction failure and aggressive disease. Identification of drug...

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Bibliographic Details
Main Authors: Valeria Tosello, Gloria Milani, Annalisa Martines, Nadia Macri, Wouder Van Loocke, Filip Matthijssens, Barbara Buldini, Sonia Minuzzo, Deborah Bongiovanni, Richard Fabian Schumacher, Alberto Amadori, Pieter Van Vlierberghe, Erich Piovan
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Cells
Subjects:
MYC-translocated leukemia
T-lineage acute lymphoblastic leukemia
NOTCH1-independent
super-enhancers
BRD4 inhibition
targeted therapy
Online Access:http://www.mdpi.com/2073-4409/7/10/160

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http://www.mdpi.com/2073-4409/7/10/160

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