Tobacco Exposure Enhances Human Papillomavirus 16 Oncogene Expression via EGFR/PI3K/Akt/c-Jun Signaling Pathway in Cervical Cancer Cells

Tobacco Exposure Enhances Human Papillomavirus 16 Oncogene Expression via EGFR/PI3K/Akt/c-Jun Signaling Pathway in Cervical Cancer Cells

High-risk human papillomavirus (HR-HPV) infection is not a sufficient condition for cervical cancer development because most infections are benign and naturally cleared. Epidemiological studies revealed that tobacco smoking is a cofactor with HR-HPV for cervical cancer initiation and progression, ev...

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Bibliographic Details
Main Authors: Juan P. Muñoz, Diego Carrillo-Beltrán, Víctor Aedo-Aguilera, Gloria M. Calaf, Oscar León, Edio Maldonado, Julio C. Tapia, Enrique Boccardo, Michelle A. Ozbun, Francisco Aguayo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Microbiology
Subjects:
cervical cancer
papillomavirus
cigarette smoke
signaling
HPV oncoproteins
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.03022/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.03022/full

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