Orienting the causal relationship between imprecisely measured traits using GWAS summary data.
Inference about the causal structure that induces correlations between two traits can be achieved by combining genetic associations with a mediation-based approach, as is done in the causal inference test (CIT). However, we show that measurement error in the phenotypes can lead to the CIT inferring...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-11-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC5711033?pdf=render |