Prolonged survival and milder impairment of motor function in the SOD1 ALS mouse model devoid of fibroblast growth factor 2

Prolonged survival and milder impairment of motor function in the SOD1 ALS mouse model devoid of fibroblast growth factor 2

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective motoneuron loss in brain and spinal cord. Mutations in the superoxide dismutase (SOD) 1 gene account for 10–20% of familial ALS patients. The ALS-mouse model over-expressing a mutant human SOD1 (G93A)...

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Bibliographic Details
Main Authors: Nadine Thau, Julia Jungnickel, Sarah Knippenberg, Andreas Ratzka, Reinhard Dengler, Susanne Petri, Claudia Grothe
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Neurodegenerative disease
Neurotrophic factors
Fibroblast growth factor 2
Ciliary neurotrophic factor
Glial derived neurotrophic factor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112001374

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http://www.sciencedirect.com/science/article/pii/S0969996112001374

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