Temozolomide in aggressive pituitary adenomas and carcinomas

Temozolomide in aggressive pituitary adenomas and carcinomas

Temozolomide is an alkylating agent used in the treatment of gliomas and, more recently, aggressive pituitary adenomas and carcinomas. Temozolomide methylates DNA and, thereby, has antitumor effects. O6-methylguanine-DNA methyltransferase, a DNA repair enzyme, removes the alkylating adducts that are...

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Bibliographic Details
Main Authors: Leon D. Ortiz, Luis V. Syro, Bernd W. Scheithauer, Fabio Rotondo, Humberto Uribe, Camilo E. Fadul, Eva Horvath, Kalman Kovacs
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2012-01-01
Series:Clinics
Subjects:
Pituitary adenoma
Pituitary carcinoma
MGMT
Temozolomide
Review
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012001300020

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012001300020

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