O6-Methylguanine-Methyltransferase (MGMT) Promoter Methylation Status in Glioma Stem-Like Cells is Correlated to Temozolomide Sensitivity Under Differentiation-Promoting Conditions

O6-Methylguanine-Methyltransferase (MGMT) Promoter Methylation Status in Glioma Stem-Like Cells is Correlated to Temozolomide Sensitivity Under Differentiation-Promoting Conditions

Glioblastoma (GBM) is the most malignant type of primary brain tumor with a very poor prognosis. The actual standard protocol of treatment for GBM patients consists of radiotherapy and concomitant temozolomide (TMZ). However, the therapeutic efficacy of this treatment is limited due to tumor recurre...

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Bibliographic Details
Main Authors: Lucie Karayan-Tapon, Sebastien Martin, Ali G. Turhan, Celine Marquant, Jean-Marc Tourani, Pierre Rivet, Michel Wager, Claire Villalva, Ulrich Cortes
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:International Journal of Molecular Sciences
Subjects:
MGMT methylation
glioma stem-like cells
temozolomide
differentiation
Online Access:http://www.mdpi.com/1422-0067/13/6/6983

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http://www.mdpi.com/1422-0067/13/6/6983

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