RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML

RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML

Acute myeloid leukemia (AML) is a heterogeneous disease caused by mutations in transcriptional regulator genes, but how different mutant regulators shape the chromatin landscape is unclear. Here, we compared the transcriptional networks of two types of AML with chromosomal translocations of the RUNX...

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Bibliographic Details
Main Authors: Justin Loke, Salam A. Assi, Maria Rosaria Imperato, Anetta Ptasinska, Pierre Cauchy, Yura Grabovska, Natalia Martinez Soria, Manoj Raghavan, H. Ruud Delwel, Peter N. Cockerill, Olaf Heidenreich, Constanze Bonifer
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
RUNX1-EVI1
RUNX1-ETO
epigenetic landscape
chromatin
transcriptional network
acute myeloid leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306113

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http://www.sciencedirect.com/science/article/pii/S2211124717306113

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