Expression of Herpes Simplex Virus Thymidine Kinase/Ganciclovir by RNA Trans-Splicing Induces Selective Killing of HIV-Producing Cells

Expression of Herpes Simplex Virus Thymidine Kinase/Ganciclovir by RNA Trans-Splicing Induces Selective Killing of HIV-Producing Cells

Antiviral strategies targeting hijacked cellular processes are less easily evaded by the virus than viral targets. If selective for viral functions, they can have a high therapeutic index. We used RNA trans-splicing to deliver the herpes simplex virus thymidine kinase-ganciclovir (HSV-tk/GCV) cell s...

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Bibliographic Details
Main Authors: Carin K. Ingemarsdotter, Sushmita Poddar, Sarah Mercier, Volker Patzel, Andrew M.L. Lever
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
HIV
RNA splicing
RNA trans-splicing
gene therapy
exon replacement
herpes simplex virus thymidine kinase-ganciclovir
HSV-tk/GCV
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117301440

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http://www.sciencedirect.com/science/article/pii/S2162253117301440

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