Amylose-Based Cationic Star Polymers for siRNA Delivery

A new siRNA delivery system using a cationic glyco-star polymer is described. Spermine-modified 8-arm amylose star polymer (with a degree of polymerization of approximately 60 per arm) was synthesized by chemoenzymatic methods. The cationic star polymer effectively bound to siRNA and formed spherica...

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Bibliographic Details
Main Authors: Tomoki Nishimura, Kaori Umezaki, Sada-atsu Mukai, Shin-ichi Sawada, Kazunari Akiyoshi
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/962941