SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis

SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis

Abstract Background Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by expression of the chimeric BCR-ABL tyrosine kinase oncogene, resulting from the t(9;22) chromosomal translocation. Imatinib (gleevec, STI-571) is a selective inhibitor of BCR-ABL activity highly effecti...

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Bibliographic Details
Main Authors: Francesca Monteleone, Simona Taverna, Riccardo Alessandro, Simona Fontana
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Curcumin
CML cells
SWATH-MS
miR-22/IPO7/HIF-1α axis
Online Access:http://link.springer.com/article/10.1186/s13046-018-0843-y

Internet

http://link.springer.com/article/10.1186/s13046-018-0843-y

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