Protective effects of the selective alpha1A-adrenoceptor antagonist silodosin against cyclophosphamide-induced cystitis in rats

Protective effects of the selective alpha1A-adrenoceptor antagonist silodosin against cyclophosphamide-induced cystitis in rats

We investigated the protective effects of a selective α1A-adrenoceptor antagonist, silodosin (Silod) on urinary bladder function in cyclophosphamide (CYP)-induced cystitis rats, with and without desensitization of the capsaicin (CAP)-sensitive afferent nerve pathway. Male Wistar rats (310–400 g) wer...

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Bibliographic Details
Main Authors: Nanxi Liu, Shogo Shimizu, Takahiro Shimizu, Kumiko Nakamura, Masaki Yamamoto, Youichirou Higashi, Motoaki Saito
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Journal of Pharmacological Sciences
Subjects:
Afferent nerve pathway
Alpha 1A-adrenoceptor antagonist
Cyclophosphamide-induced cystitis
Intercontraction interval
Silodosin
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316301141

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http://www.sciencedirect.com/science/article/pii/S1347861316301141

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