Association of <i>NUDT15</i>*3 and <i>FPGS</i> 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia

Association of <i>NUDT15</i>*3 and <i>FPGS</i> 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia

Genetic variants influencing the pharmacokinetics and/or pharmacodynamics of the chemotherapeutic drugs used in Acute Lymphoblastic Leukemia (ALL) therapy often contribute to the occurrence of treatment related toxicity (TRT). In this study, we explored the association of candidate genetic variants...

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Bibliographic Details
Main Authors: Sunitha Kodidela, Patchava Dorababu, Dimpal N Thakkar, Biswajit Dubashi, Rajan Sundaram, Niveditha Muralidharan, Ravi Prasad Nidanapu, Anil Aribandi, Suresh Chandra Pradhan, Chakradhara Rao Satyanarayana Uppugunduri
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Genes
Subjects:
NUDT15
polymorphism
toxicity
6-mercaptopurine
relapse
survival
Online Access:https://www.mdpi.com/2073-4425/11/6/594

Internet

https://www.mdpi.com/2073-4425/11/6/594

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