Differential Expression of Sirtuins in the Ageing Rat Brain

Although there are seven mammalian sirtuins (SIRT1-7), little is known about their expression in the ageing brain. To characterise the change(s) in mRNA and protein expression of SIRT1-7 and their associated proteins in the brain of ‘physiologically’ aged Wistar rats. We tested mRNA and protein expr...

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Bibliographic Details
Main Authors: Gilles J. Guillemin, Nady eBraidy
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
p53
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00167/full