Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression

Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression

Abstract Hwang et al. recently showed that VGF substantially contributes to the resistance of human lung cancer cells towards epidermal growth factor receptor kinase inhibitors. This was further linked to enhanced epithelial–mesenchymal transition. Here, we demonstrate that VGF is epigenetically mod...

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Bibliographic Details
Main Authors: Sebastian Marwitz, Lena Heinbockel, Swetlana Scheufele, Dörte Nitschkowski, Christian Kugler, Sven Perner, Martin Reck, Ole Ammerpohl, Torsten Goldmann
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Clinical Epigenetics
Subjects:
VGF
Methylome
Transcriptome
Non-small cell lung cancer
NSCLC
Online Access:http://link.springer.com/article/10.1186/s13148-017-0423-6

Internet

http://link.springer.com/article/10.1186/s13148-017-0423-6

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