The Spindle-Associated Microcephaly Protein, WDR62, Is Required for Neurogenesis and Development of the Hippocampus

The Spindle-Associated Microcephaly Protein, WDR62, Is Required for Neurogenesis and Development of the Hippocampus

Primary microcephaly genes (MCPH) are required for the embryonic expansion of the mammalian cerebral cortex. However, MCPH mutations may spare growth in other regions of the developing forebrain which reinforces context-dependent functions for distinct MCPH genes in neurodevelopment. Mutations in th...

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Bibliographic Details
Main Authors: Belal Shohayeb, Uda Y. Ho, Halah Hassan, Michael Piper, Dominic C. H. Ng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
microcephaly
radial glia
hippocampus
neural proliferation
neural migration
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.549353/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.549353/full

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