Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart

Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart

Abstract It is well established that the aging heart progressively remodels towards a senescent phenotype, but alterations of cellular microstructure and their differences to chronic heart failure (HF) associated remodeling remain ill-defined. Here, we show that the transverse tubular system (t-syst...

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Bibliographic Details
Main Authors: Yankun Lyu, Vipin K. Verma, Younjee Lee, Iosif Taleb, Rachit Badolia, Thirupura S. Shankar, Christos P. Kyriakopoulos, Craig H. Selzman, William Caine, Rami Alharethi, Sutip Navankasattusas, Thomas Seidel, Stavros G. Drakos, Frank B. Sachse
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:npj Aging and Mechanisms of Disease
Online Access:https://doi.org/10.1038/s41514-021-00066-7

Internet

https://doi.org/10.1038/s41514-021-00066-7

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