Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity[S]

Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity[S]

Autophagy is a catabolic process involved in maintaining energy and organelle homeostasis. The relationship between obesity and the regulation of autophagy is cell type specific. Despite adverse consequences of obesity on cardiac structure and function, the contribution of altered cardiac autophagy...

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Bibliographic Details
Main Authors: Bharat Jaishy, Quanjiang Zhang, Heaseung S. Chung, Christian Riehle, Jamie Soto, Stephen Jenkins, Patrick Abel, L.Ashley Cowart, Jennifer E. Van Eyk, E.Dale Abel
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Journal of Lipid Research
Subjects:
fatty acids
lysosomes
autophagy
protein kinase Cβ
NADPH oxidase 2
cardiomyocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752035584X

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http://www.sciencedirect.com/science/article/pii/S002222752035584X

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