Identity by descent mapping of founder mutations in cancer using high-resolution tumor SNP data.

Identity by descent mapping of founder mutations in cancer using high-resolution tumor SNP data.

Dense genotype data can be used to detect chromosome fragments inherited from a common ancestor in apparently unrelated individuals. A disease-causing mutation inherited from a common founder may thus be detected by searching for a common haplotype signature in a sample population of patients. We pr...

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Bibliographic Details
Main Authors: Eric Letouzé, Aliou Sow, Fabien Petel, Roberto Rosati, Bonald C Figueiredo, Nelly Burnichon, Anne-Paule Gimenez-Roqueplo, Enzo Lalli, Aurélien de Reyniès
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22567117/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22567117/pdf/?tool=EBI

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