Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy.

Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy.

Progressive aggregation of protein Tau into oligomers and fibrils correlates with cognitive decline and synaptic dysfunction, leading to neurodegeneration in vulnerable brain regions in Alzheimer's disease. The unmet need of effective therapy for Alzheimer's disease, combined with problema...

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Bibliographic Details
Main Authors: Clara Theunis, Natalia Crespo-Biel, Valérie Gafner, Maria Pihlgren, María Pilar López-Deber, Pedro Reis, David T Hickman, Oskar Adolfsson, Nathalie Chuard, Dorin Mlaki Ndao, Peter Borghgraef, Herman Devijver, Fred Van Leuven, Andrea Pfeifer, Andreas Muhs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3747157?pdf=render

Internet

http://europepmc.org/articles/PMC3747157?pdf=render

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