Remodelling of the bone marrow microenvironment by stromal hyaluronan modulates the malignancy of breast cancer cells

Remodelling of the bone marrow microenvironment by stromal hyaluronan modulates the malignancy of breast cancer cells

Abstract Background Hyaluronan (HA) is an abundant component of the bone marrow (BM) extracellular matrix. Here, we investigated the abnormal deposition of HA in the BM microenvironment and its remodelling in mediating the malignancy of breast cancer cells (BCCs). Methods BCCs were transplanted into...

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Bibliographic Details
Main Authors: Xiaoyan Chen, Xiaoxing Shi, Yiwen Liu, Yiqing He, Yan Du, Guoliang Zhang, Cuixia Yang, Feng Gao
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cell Communication and Signaling
Subjects:
Hyaluronan
Mammary tumour
Bone metastasis
Bone marrow stromal cells
Online Access:http://link.springer.com/article/10.1186/s12964-020-00592-z

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http://link.springer.com/article/10.1186/s12964-020-00592-z

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