The under-appreciated promiscuity of the epidermal growth factor receptor family.

Each member of the epidermal growth factor receptor (EGFR) family plays a key role in normal development, homeostasis and a variety of pathophysiological conditions, most notably in cancer. According to the prevailing dogma, these four receptor tyrosine kinases (RTKs; EGFR, ERBB2, ERBB3 and ERBB4) f...

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Bibliographic Details
Main Authors: Sean P Kennedy, Jordan F Hastings, Jeremy Z.R. Han, David R Croucher
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00088/full