C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera

C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera

Systemic complement activation drives a plethora of pathological conditions, but its role in snake envenoming remains obscure. Here, we explored complement’s contribution to the physiopathogenesis of Naja annulifera envenomation. We found that N. annulifera venom promoted the generation of C3a, C4a,...

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Bibliographic Details
Main Authors: Felipe Silva de França, Isadora Maria Villas-Boas, Bruno Cogliati, Trent M. Woodruff, Edimara da Silva Reis, John D. Lambris, Denise V. Tambourgi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
Naja snake venom
envenomation
complement system
C5a-C5aR1
complement inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.652242/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.652242/full

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