The MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes

The MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes

JC polyomavirus (JCPyV) is a neuroinvasive pathogen causing a fatal, demyelinating disease of the central nervous system (CNS) known as progressive multifocal leukoencephalopathy (PML). Within the CNS, JCPyV predominately targets two cell types: oligodendrocytes and astrocytes. The underlying mechan...

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Bibliographic Details
Main Authors: Michael P. Wilczek, Francesca J. Armstrong, Remi P. Geohegan, Colleen L. Mayberry, Jeanne K. DuShane, Benjamin L. King, Melissa S. Maginnis
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Viruses
Subjects:
JC polyomavirus
progressive multifocal leukoencephalopathy (PML)
astrocytes
RNA sequencing
bioinformatics
Online Access:https://www.mdpi.com/1999-4915/13/9/1834

Internet

https://www.mdpi.com/1999-4915/13/9/1834

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