Anti-TNFα therapy in IBD alters brain activity reflecting visceral sensory function and cognitive-affective biases.

Anti-TNFα therapy in IBD alters brain activity reflecting visceral sensory function and cognitive-affective biases.

In inflammatory bowel disease (IBD), immune activation with increased circulating TNF-α is linked to the intensity of gastrointestinal symptoms and depression or anxiety. A central feature of depression is cognitive biases linked to negative attributions about self, the world and the future. We aime...

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Bibliographic Details
Main Authors: Marcus A Gray, Che-Yung Chao, Heidi M Staudacher, Natasha A Kolosky, Nicholas J Talley, Gerald Holtmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5843226?pdf=render

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http://europepmc.org/articles/PMC5843226?pdf=render

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