The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models

Abstract Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to acco...

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Bibliographic Details
Main Authors: Rui C. Oliveira, Ana Margarida Abrantes, José Guilherme Tralhão, Maria Filomena Botelho
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:Animal Models and Experimental Medicine
Subjects:
Online Access:https://doi.org/10.1002/ame2.12102