MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells.

MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells.

Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate. However, prior studies have not determined precisely when, and in which cell types, MYC is induced. Using immunohistochemistry (IHC) to local...

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Bibliographic Details
Main Authors: Tsuyoshi Iwata, Denise Schultz, Jessica Hicks, Gretchen K Hubbard, Laura N Mutton, Tamara L Lotan, Carlise Bethel, Matthew T Lotz, Srinivasan Yegnasubramanian, William G Nelson, Chi V Dang, MengMeng Xu, Uzoma Anele, Cheryl M Koh, Charles J Bieberich, Angelo M De Marzo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2828486?pdf=render

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http://europepmc.org/articles/PMC2828486?pdf=render

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