Rhinovirus infection results in stronger and more persistent genomic dysregulation: Evidence for altered innate immune response in asthmatics at baseline, early in infection, and during convalescence.

Rhinovirus infection results in stronger and more persistent genomic dysregulation: Evidence for altered innate immune response in asthmatics at baseline, early in infection, and during convalescence.

BACKGROUND:Rhinovirus (HRV) is associated with the large majority of virus-induced asthma exacerbations in children and young adults, but the mechanisms remain poorly defined. METHODS:Asthmatics and non-asthmatic controls were inoculated with HRV-A16, and nasal epithelial samples were obtained 7 day...

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Main Authors: Peter W Heymann, Huyen-Tran Nguyen, John W Steinke, Ronald B Turner, Judith A Woodfolk, Thomas A E Platts-Mills, Lisa Martin, Hua He, Jocelyn Biagini Myers, Mark Lindsey, Umasundari Sivaprasad, Mario Medvedovic, Naim Mahi, Holliday Carper, Deborah D Murphy, James Patrie, Gurjit K Khurana Hershey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5446117?pdf=render

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http://europepmc.org/articles/PMC5446117?pdf=render

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