Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse

Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse

Mammalian NIMA-like kinase-1 (NEK1) is a dual-specificity kinase highly expressed in mouse germ cells during prophase I of meiosis. Loss of NEK1 induces retention of cohesin on chromosomes at meiotic prophase I. Timely deposition and removal of cohesin is essential for accurate chromosome segregatio...

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Bibliographic Details
Main Authors: Miguel A. Brieño-Enríquez, Stefannie L. Moak, Melissa Toledo, Joshua J. Filter, Stephen Gray, José L. Barbero, Paula E. Cohen, J. Kim Holloway
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
meiosis
cohesin
mouse
NIMA-like kinase
WAPL
prophase pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716313158

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http://www.sciencedirect.com/science/article/pii/S2211124716313158

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