The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

The human Aβ peptide causes progressive paralysis when expressed in the muscles of the nematode worm, C. elegans. We have exploited this model of Aβ toxicity by carrying out an RNAi screen to identify genes whose reduced expression modifies the severity of this locomotor phenotype. Our initial findi...

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Bibliographic Details
Main Authors: Eleonora Khabirova, Aileen Moloney, Stefan J Marciniak, Julie Williams, David A Lomas, Stephen G Oliver, Giorgio Favrin, David B Sattelle, Damian C Crowther
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4117641?pdf=render

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http://europepmc.org/articles/PMC4117641?pdf=render

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