Synthesis of alpha-tetrasubstituted triazoles by copper-catalyzed silyl deprotection/azide cycloaddition

Synthesis of alpha-tetrasubstituted triazoles by copper-catalyzed silyl deprotection/azide cycloaddition

Propargylamines are popular substrates for triazole formation, but tetrasubstituted variants have required multistep syntheses involving stoichiometric amounts of metal. A recent cyclohexanone–amine–silylacetylene coupling forms silyl-protected tetrasubstituted propargylamines in a single copper-cat...

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Bibliographic Details
Main Authors: Zachary L. Palchak, Paula T. Nguyen, Catharine H. Larsen
Format: Article
Language:English
Published: Beilstein-Institut 2015-08-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
azide
copper catalysis
multicomponent reactions
tetrasubstituted carbon
triazole
Online Access:https://doi.org/10.3762/bjoc.11.154

Internet

https://doi.org/10.3762/bjoc.11.154

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