Down-regulation of Survivin by Antisense Oligonucleotides Increases Apoptosis, Inhibits Cytokinesis and Anchorage-Independent Growth

Down-regulation of Survivin by Antisense Oligonucleotides Increases Apoptosis, Inhibits Cytokinesis and Anchorage-Independent Growth

Survivin, a member of the inhibitor of apoptosis protein (IAP) family, is detected in most common human cancers but not in adjacent normal cells. Previous studies suggest that survivin associates with the mitotic spindle and directly inhibits caspase activity. To further investigate the function of...

Full description

Bibliographic Details
Main Authors: Jun Chen, Wei Wu, Stephen K. Tahir, Paul E. Kroeger, Saul H. Rosenberg, Lex M. Cowsert, Frank Bennett, Stanislaw Krajewski, Maryla Krajewska, Kate Welsh, John C. Reed, Shi-Chung Ng
Format: Article
Language:English
Published: Elsevier 2000-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
survivin
apoptosis
antisense
oligonucleotides
cytokinesis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558600800329

Internet

http://www.sciencedirect.com/science/article/pii/S1476558600800329

Similar Items