Early Seizures Prematurely Unsilence Auditory Synapses to Disrupt Thalamocortical Critical Period Plasticity

Early Seizures Prematurely Unsilence Auditory Synapses to Disrupt Thalamocortical Critical Period Plasticity

Heightened neural excitability in infancy and childhood results in increased susceptibility to seizures. Such early-life seizures are associated with language deficits and autism that can result from aberrant development of the auditory cortex. Here, we show that early-life seizures disrupt a critic...

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Bibliographic Details
Main Authors: Hongyu Sun, Anne E. Takesian, Ting Ting Wang, Jocelyn J. Lippman-Bell, Takao K. Hensch, Frances E. Jensen
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Subjects:
epilepsy
development
tonotopic plasticity
auditory cortex
AMPA receptor
NMDA receptor
NBQX
silent synapses
autism
neurodevelopmental disorders
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471830706X

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http://www.sciencedirect.com/science/article/pii/S221112471830706X

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