Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease

Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease

To investigate whether the endogenous neuropeptide nociceptin/orphanin FQ (N/OFQ) contributes to the death of dopamine neurons in Parkinson's disease, we undertook a genetic and a pharmacological approach using NOP receptor knockout (NOP−/−) mice, and the selective and potent small molecule NOP...

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Bibliographic Details
Main Authors: Ludovico Arcuri, Riccardo Viaro, Simone Bido, Francesco Longo, Mariangela Calcagno, Pierre-Olivier Fernagut, Nurulain T. Zaveri, Girolamo Calò, Erwan Bezard, Michele Morari
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Neurobiology of Disease
Subjects:
Adeno associated viral vectors
α-Synuclein
Nociceptin/orphanin FQ
MPP+
MPTP
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611630016X

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http://www.sciencedirect.com/science/article/pii/S096999611630016X

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