Meta-Analysis of Genome-Wide Association and Gene Expression Studies Implicates Donor T Cell Function and Cytokine Pathways in Acute GvHD

Meta-Analysis of Genome-Wide Association and Gene Expression Studies Implicates Donor T Cell Function and Cytokine Pathways in Acute GvHD

Graft-vs.-host disease (GvHD) is a major complication after allogeneic hematopoietic stem cell transplantation that causes mortality and severe morbidity. Genetic disparities in human leukocyte antigens between the recipient and donor are known contributors to the risk of the disease. However, the o...

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Bibliographic Details
Main Authors: Kati Hyvärinen, Satu Koskela, Riitta Niittyvuopio, Anne Nihtinen, Liisa Volin, Urpu Salmenniemi, Mervi Putkonen, Ismael Buño, David Gallardo, Maija Itälä-Remes, Jukka Partanen, Jarmo Ritari
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
GvHD
GWAS
gene expression
meta-analysis
HSCT
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00019/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00019/full

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