Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with α-synucleinopathies

Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with α-synucleinopathies

Substantial interest persists for developing neurotrophic factors to treat neurodegenerative diseases. At the same time, significant progress has been made in implementing gene therapy as a means to provide long-term expression of bioactive neurotrophic factors to targeted sites in the brain. Noneth...

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Bibliographic Details
Main Authors: R.T. Bartus, J.H. Kordower, E.M. Johnson, Jr., L. Brown, B.R. Kruegel, Y. Chu, T.L. Baumann, A.E. Lang, C.W. Olanow, C.D. Herzog
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Neurobiology of Disease
Subjects:
Neurotrophic factors
Parkinson's disease
Alpha-synuclein
Synucleinopathies
Axonal transport deficiency
Gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000959

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http://www.sciencedirect.com/science/article/pii/S0969996115000959

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