Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling

Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling

Abstract Background Meningiomas are the most common primary intracranial tumors in adults. While a majority of meningiomas are slow growing neoplasms that may cured by surgical resection, a subset demonstrates more aggressive behavior and insidiously recurs despite surgery and radiation, without eff...

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Bibliographic Details
Main Authors: Yu Mei, Ziming Du, Changchen Hu, Noah F. Greenwald, Malak Abedalthagafi, Nathalie Y.R. Agar, Gavin P. Dunn, Wenya Linda Bi, Sandro Santagata, Ian F. Dunn
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Cell Communication and Signaling
Subjects:
Osteoglycin
Autophagy
AKT inhibitor
Meningioma
Neurofibromatosis type 2
Mammalian target of rapamycin complex 1
Online Access:http://link.springer.com/article/10.1186/s12964-017-0189-7

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http://link.springer.com/article/10.1186/s12964-017-0189-7

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