Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma

Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma

Background: Adrenocortical carcinoma (ACC) is a rare tumor entity with restricted therapeutic opportunities. HSP90 (Heat Shock Protein 90) chaperone activity is fundamental for cell survival and contributes to different oncogenic signaling pathways. Indeed, agents targeting HSP90 function have shown...

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Bibliographic Details
Main Authors: Claudia Siebert, Denis Ciato, Masanori Murakami, Ludwig Frei-Stuber, Luis Gustavo Perez-Rivas, José Luis Monteserin-Garcia, Svenja Nölting, Julian Maurer, Annette Feuchtinger, Axel K. Walch, Harm R. Haak, Jérôme Bertherat, Massimo Mannelli, Martin Fassnacht, Esther Korpershoek, Martin Reincke, Günter K. Stalla, Constanze Hantel, Felix Beuschlein
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Endocrinology
Subjects:
adrenal gland
cortisol
N-terminal HSP90 inhibitors
C-terminal HSP90 inhibitors
prognostic marker
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00487/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00487/full

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