ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts

ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts

Bone homeostasis is a metabolic balance between the new bone formation by osteoblasts and old bone resorption by osteoclasts. Excessive osteoclastic bone resorption results in low bone mass, which is the major cause of bone diseases such as rheumatoid arthritis. Small GTPases Rac1 is a key regulator...

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Bibliographic Details
Main Authors: Xinyue Liang, Yafei Hou, Lijuan Han, Shuxiang Yu, Yunyun Zhang, Xiumei Cao, Jianshe Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ELMO1
osteoclast differentiation
bone resorption
adhesion
migration
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.702916/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.702916/full

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