Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis.

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis.

The reductively activated nitroaromatic class of antimicrobials, which include nitroimidazole and the more metabolically labile nitrofuran antitubercular agents, have demonstrated some potential for development as therapeutics against dormant TB bacilli. In previous studies, the pharmacokinetic prop...

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Bibliographic Details
Main Authors: Rakesh, David F Bruhn, Michael S Scherman, Lisa K Woolhiser, Dora B Madhura, Marcus M Maddox, Aman P Singh, Robin B Lee, Julian G Hurdle, Michael R McNeil, Anne J Lenaerts, Bernd Meibohm, Richard E Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3914891?pdf=render

Internet

http://europepmc.org/articles/PMC3914891?pdf=render

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