Mechanism and consequence of abnormal calcium homeostasis in Rett syndrome astrocytes

Mechanism and consequence of abnormal calcium homeostasis in Rett syndrome astrocytes

Astrocytes play an important role in Rett syndrome (RTT) disease progression. Although the non-cell-autonomous effect of RTT astrocytes on neurons was documented, cell-autonomous phenotypes and mechanisms within RTT astrocytes are not well understood. We report that spontaneous calcium activity is a...

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Bibliographic Details
Main Authors: Qiping Dong, Qing Liu, Ronghui Li, Anxin Wang, Qian Bu, Kuan Hong Wang, Qiang Chang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
Rett syndrome
MeCP2
astrocytes
calcium
Online Access:https://elifesciences.org/articles/33417

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