Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway

Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway

Interferon γ (IFN-γ) was shown to be a macrophage activating factor already in 1984. Consistently, inborn errors of IFN-γ immunity underlie Mendelian Susceptibility to Mycobacterial Disease (MSMD). MSMD is characterized by genetic predisposition to disease caused by weakly...

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Bibliographic Details
Main Authors: Kathrin Haake, Anna-Lena Neehus, Theresa Buchegger, Mark Philipp Kühnel, Patrick Blank, Friederike Philipp, Carmen Oleaga-Quintas, Ansgar Schulz, Michael Grimley, Ralph Goethe, Danny Jonigk, Ulrich Kalinke, Stéphanie Boisson-Dupuis, Jean-Laurent Casanova, Jacinta Bustamante, Nico Lachmann
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
hematopoiesis
induced pluripotent stem cells
macrophages
msmd
mycobacteria
interferon γ
Online Access:https://www.mdpi.com/2073-4409/9/2/483

Internet

https://www.mdpi.com/2073-4409/9/2/483

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